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KMID : 1023420150150060800
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Journal of Dental Hygiene Science
2015 Volume.15 No. 6 p.800 ~ p.806
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Analgesic Effects of Triptolide and N-nitro-L-arginine Methyl Ester in Rat’s Temporomandibular Joint Pain Model
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Kim Yun-Kyung
Lee Min-Kyung
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Abstract
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The aim of this study was to investigate whether intracisternal administrations of triptolide and N-nitro-L-arginine Methyl Ester (L-NAME) are involved in the regulation of temporomandibular joint (TMJ) pain. The TMJ pain was induced by the injection of 5% formalin (30 μl) into TMJ capsule of rats. The pain behavioral responses was recorded the number of grooming or scratching on the left TMJ area for 9 successive 5 minutes intervals. Triptolide and L-NAME were administrated intracisternally 10 minutes before formalin injection. The intra-articular injection of formalin produced a biphasic pattern of pain response (first phase: 0∼10 minutes and second phase: 11∼45 minutes). The intracisternal administration of triptolide (1 μg/10 μl) and L-NAME (0.1 μg/10 μl) suppressed the TMJ pain behavior in each experiment. Co-administration of two drugs was shown the enhanced effect than the analgesic effect by single-administration of triptolide (1 μg/10 μl). The triptolide could be a useful analgesic agent for the treatment of TMJ pain, and it is expected to reduce the substantial amount of it via co-administration of synthetic chemical compound and natural products.
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KEYWORD
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Analgesic effect, L-NAME, Pain, Temporomandibular joint, Triptolide
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